The host response to allogeneic and xenogeneic biological scaffold materials.
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276The host response to allogeneic and xenogeneic biological scaffold materials.
Auteurs : Timothy J. Keane [États-Unis] ; Stephen F. BadylakSource :
- Journal of tissue engineering and regenerative medicine [ 1932-7005 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Peau.
- métabolisme : Matrice extracellulaire.
- Animaux, Humains, Immunité acquise, Immunité innée, Ingénierie tissulaire, Matériaux biocompatibles, Structures d'échafaudage tissulaires, Système immunitaire, Transplantation homologue, Épitopes.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Biocompatible Materials, Epitopes.
- metabolism : Extracellular Matrix.
- methods : Tissue Engineering.
- pathology : Skin.
- Adaptive Immunity, Animals, Humans, Immune System, Immunity, Innate, Tissue Scaffolds, Transplantation, Homologous.
Abstract
The clinical use of biological scaffold materials has become commonplace. Such scaffolds are composed of extracellular matrix (ECM), or components of ECM, derived from allogeneic or xenogeneic tissues. Such scaffold materials vary widely in their source tissue, processing methods and sterilization methods. The success or failure of an ECM scaffold for a given application is dependent on the host response following implantation; a response that is largely mediated by the innate immune system and which is influenced by a numerous factors, including the processing methods used in the preparation of biological scaffolds. The present paper reviews various aspects of the host response to biological scaffolds and factors that affect this response. In addition, some of the logistical, regulatory and reconstructive implications associated with the use of biological scaffolds are discussed.
DOI: 10.1002/term.1874
PubMed: 24668694
Affiliations:
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Le document en format XML
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<term>Humans</term>
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<term>Matrice extracellulaire (métabolisme)</term>
<term>Matériaux biocompatibles ()</term>
<term>Peau (anatomopathologie)</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Système immunitaire</term>
<term>Transplantation homologue</term>
<term>Épitopes ()</term>
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<term>Matériaux biocompatibles</term>
<term>Structures d'échafaudage tissulaires</term>
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<front><div type="abstract" xml:lang="en">The clinical use of biological scaffold materials has become commonplace. Such scaffolds are composed of extracellular matrix (ECM), or components of ECM, derived from allogeneic or xenogeneic tissues. Such scaffold materials vary widely in their source tissue, processing methods and sterilization methods. The success or failure of an ECM scaffold for a given application is dependent on the host response following implantation; a response that is largely mediated by the innate immune system and which is influenced by a numerous factors, including the processing methods used in the preparation of biological scaffolds. The present paper reviews various aspects of the host response to biological scaffolds and factors that affect this response. In addition, some of the logistical, regulatory and reconstructive implications associated with the use of biological scaffolds are discussed.</div>
</front>
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